The role of antisense long noncoding RNA in small RNA-triggered gene activation

Study of Long Noncoding RNA FER1L4 and RB1, as Its Competing Endogenous RNA Network Target Gene, in Breast Cancer

Introduction: Breast cancer is the second most common cause of cancer-related death among females, which requires an exploration for markers to propose a more specific categorization of this cancer. Long noncoding RNAs (lncRNAs), the main subset of noncoding transcripts, are involved in tumorigenic processes. In this study, we investigated the expression of the fer-­1–­like family member 4 (FER...

A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies

Dysregulation of the insulin-like growth factor type I receptor (IGF1R) has been implicated in the progression and therapeutic resistance of malignancies. In acute myeloid leukemia (AML) cells, IGF1R is one of the most abundantly phosphorylated receptor tyrosine kinases, promoting cell growth through the PI3K/Akt signaling pathway. However, little is known regarding the molecular mechanisms und...

RNA Isolation (Small RNA Extraction). Fatemeh Mehrpooyan*

Long Noncoding RNA-GAS5

The “ ” ( ) transcript NF - ĸB interacting long noncoding RNA NKILA is antisense to cancer - associated gene PMEPA

This correspondence concerns a recent publication in by Liu et al. Cancer Cell who analyzed a long noncoding RNA (lncRNA) that they designated “ ”. NKILA Liu et al. found that (1) is upregulated by immunostimulants, (2) has a NKILA promoter with an NF-ĸB binding motif, (3) can bind to the p65 protein of the NF-ĸB transcription factor and then interfere with phosphorylation of IĸBα, and (4) nega...